Regulatory Role of Interleukin-10 and Interferon-y in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected with Schistosoma japonicum
Identifieur interne : 008A87 ( Main/Exploration ); précédent : 008A86; suivant : 008A88Regulatory Role of Interleukin-10 and Interferon-y in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected with Schistosoma japonicum
Auteurs : Violaine Amaud [France] ; JUN LI [République populaire de Chine] ; YUANYUAN WANG [République populaire de Chine] ; XIAO FU [République populaire de Chine] ; SHI MENGZHI [République populaire de Chine] ; XINSONG LUO [République populaire de Chine] ; XUNYA HOU [République populaire de Chine] ; Helia Dessein [France] ; ZHOU JIE [République populaire de Chine] ; Xin-Ling Yu [République populaire de Chine] ; HONGBIN HE [France, République populaire de Chine] ; Donald P. Mcmanus [Australie] ; YUESHENG LI [République populaire de Chine, Australie] ; Alain Dessein [France]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background. Schistosoma japonicum is the most pathogenic agent of hepatosplenic schistosomiasis. It causes fibrosis of the central (CentF) and peripheral (PerF) portal areas. We investigated whether CentF and PerF in Chinese fishermen infected with S. japonicum were associated with an abnormal production of cytokines and chemokines that, in experimental models, have been implicated in the regulation of fibrosis. Methods. Cytokines were measured by enzyme-linked immunosorbent assay in cultures of peripheral blood mononuclear cells from 127 patients, after stimulation with S. japonicum egg antigens. Data were analyzed by logistic regression that included age, sex, number of treatment episodes, alcohol use, and exposure as covariates. Results. CentF was associated with low levels of interleukin (IL)-10 (P = .0004), regulated on activation normally T cell expressed and secreted (P = .0004), and macrophage inflammatory protein-lα (P =.007). In a multivariate analysis, only IL-10 was associated with CentF (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.2-38; P =.0004). Splenomegaly was also associated with low IL-10 production and, independently, with CentF. In multivariate analysis, PerF was associated with low production ofinterferon (IFN)-γ (OR, 8.2; 95% CI, 2-33; P =.00 3 5 ) but not with production of IL-10. Conclusions. IL-10 is associated with protection against central fibrosis, because of its anti-inflammatory and antifibrosis effects. IFN-y is associated with protection against PerF, which depends more on egg load and egg-associated toxicity.
Affiliations:
- Australie, France, République populaire de Chine
- Provence-Alpes-Côte d'Azur
- Marseille
- Université d'Aix-Marseille
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Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Shi Mengzhi" sort="Shi Mengzhi" uniqKey="Shi Mengzhi" last="Shi Mengzhi">SHI MENGZHI</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Xinsong Luo" sort="Xinsong Luo" uniqKey="Xinsong Luo" last="Xinsong Luo">XINSONG LUO</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Xunya Hou" sort="Xunya Hou" uniqKey="Xunya Hou" last="Xunya Hou">XUNYA HOU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Dessein, Helia" sort="Dessein, Helia" 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Jie">ZHOU JIE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Xin Ling" sort="Yu, Xin Ling" uniqKey="Yu X" first="Xin-Ling" last="Yu">Xin-Ling Yu</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 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type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Mcmanus, Donald P" sort="Mcmanus, Donald P" uniqKey="Mcmanus D" first="Donald P." last="Mcmanus">Donald P. Mcmanus</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Yuesheng Li" sort="Yuesheng Li" uniqKey="Yuesheng Li" last="Yuesheng Li">YUESHENG LI</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, Unité 399</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Unité 399</wicri:noRegion><wicri:noRegion>INSERM, Unité 399</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Aix Marseille Université, Faculté de Médecine</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0388457</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0388457 INIST</idno><idno type="RBID">Pascal:08-0388457</idno><idno type="wicri:Area/PascalFrancis/Corpus">003374</idno><idno type="wicri:Area/PascalFrancis/Curation">002C78</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002F58</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002F58</idno><idno type="wicri:doubleKey">0022-1899:2008:Amaud V:regulatory:role:of</idno><idno 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aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Jun Li" sort="Jun Li" uniqKey="Jun Li" last="Jun Li">JUN LI</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Yuanyuan Wang" sort="Yuanyuan Wang" uniqKey="Yuanyuan Wang" last="Yuanyuan Wang">YUANYUAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Xiao Fu" sort="Xiao Fu" uniqKey="Xiao Fu" last="Xiao Fu">XIAO FU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Shi Mengzhi" sort="Shi Mengzhi" uniqKey="Shi Mengzhi" last="Shi Mengzhi">SHI MENGZHI</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Xinsong Luo" sort="Xinsong Luo" uniqKey="Xinsong Luo" last="Xinsong Luo">XINSONG LUO</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Xunya Hou" sort="Xunya Hou" uniqKey="Xunya Hou" last="Xunya Hou">XUNYA HOU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Dessein, Helia" sort="Dessein, Helia" uniqKey="Dessein H" first="Helia" last="Dessein">Helia Dessein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, Unité 399</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Unité 399</wicri:noRegion><wicri:noRegion>INSERM, Unité 399</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Aix Marseille Université, Faculté de Médecine</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Zhou Jie" sort="Zhou Jie" uniqKey="Zhou Jie" last="Zhou Jie">ZHOU JIE</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Xin Ling" sort="Yu, Xin Ling" uniqKey="Yu X" first="Xin-Ling" last="Yu">Xin-Ling Yu</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Hongbin He" sort="Hongbin He" uniqKey="Hongbin He" last="Hongbin He">HONGBIN HE</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, Unité 399</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Unité 399</wicri:noRegion><wicri:noRegion>INSERM, Unité 399</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Aix Marseille Université, Faculté de Médecine</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation></author><author><name sortKey="Mcmanus, Donald P" sort="Mcmanus, Donald P" uniqKey="Mcmanus D" first="Donald P." last="Mcmanus">Donald P. Mcmanus</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Yuesheng Li" sort="Yuesheng Li" uniqKey="Yuesheng Li" last="Yuesheng Li">YUESHENG LI</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Center for Research and Control on Schistosomiasis in Lake Region</s1><s2>Yueyang</s2><s3>CHN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Yueyang</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, Unité 399</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Unité 399</wicri:noRegion><wicri:noRegion>INSERM, Unité 399</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Aix Marseille Université, Faculté de Médecine</s1><s2>Marseille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hepatic fibrosis</term><term>Human</term><term>Infection</term><term>Interferon</term><term>Interleukin 10</term><term>Microbiology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Interleukine 10</term><term>Interféron</term><term>Microbiologie</term><term>Fibrose hépatique</term><term>Infection</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Schistosoma japonicum is the most pathogenic agent of hepatosplenic schistosomiasis. It causes fibrosis of the central (CentF) and peripheral (PerF) portal areas. We investigated whether CentF and PerF in Chinese fishermen infected with S. japonicum were associated with an abnormal production of cytokines and chemokines that, in experimental models, have been implicated in the regulation of fibrosis. Methods. Cytokines were measured by enzyme-linked immunosorbent assay in cultures of peripheral blood mononuclear cells from 127 patients, after stimulation with S. japonicum egg antigens. Data were analyzed by logistic regression that included age, sex, number of treatment episodes, alcohol use, and exposure as covariates. Results. CentF was associated with low levels of interleukin (IL)-10 (P = .0004), regulated on activation normally T cell expressed and secreted (P = .0004), and macrophage inflammatory protein-lα (P =.007). In a multivariate analysis, only IL-10 was associated with CentF (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.2-38; P =.0004). Splenomegaly was also associated with low IL-10 production and, independently, with CentF. In multivariate analysis, PerF was associated with low production ofinterferon (IFN)-γ (OR, 8.2; 95% CI, 2-33; P =.00 3 5 ) but not with production of IL-10. Conclusions. IL-10 is associated with protection against central fibrosis, because of its anti-inflammatory and antifibrosis effects. IFN-y is associated with protection against PerF, which depends more on egg load and egg-associated toxicity.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>République populaire de Chine</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Amaud, Violaine" sort="Amaud, Violaine" uniqKey="Amaud V" first="Violaine" last="Amaud">Violaine Amaud</name></noRegion><name sortKey="Amaud, Violaine" sort="Amaud, Violaine" uniqKey="Amaud V" first="Violaine" last="Amaud">Violaine Amaud</name><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><name sortKey="Dessein, Helia" sort="Dessein, Helia" uniqKey="Dessein H" first="Helia" last="Dessein">Helia Dessein</name><name sortKey="Dessein, Helia" sort="Dessein, Helia" uniqKey="Dessein H" first="Helia" last="Dessein">Helia Dessein</name><name sortKey="Hongbin He" sort="Hongbin He" uniqKey="Hongbin He" last="Hongbin He">HONGBIN HE</name><name sortKey="Hongbin He" sort="Hongbin He" uniqKey="Hongbin He" last="Hongbin He">HONGBIN HE</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Jun Li" sort="Jun Li" uniqKey="Jun Li" last="Jun Li">JUN LI</name></noRegion><name sortKey="Hongbin He" sort="Hongbin He" uniqKey="Hongbin He" last="Hongbin He">HONGBIN HE</name><name sortKey="Shi Mengzhi" sort="Shi Mengzhi" uniqKey="Shi Mengzhi" last="Shi Mengzhi">SHI MENGZHI</name><name sortKey="Xiao Fu" sort="Xiao Fu" uniqKey="Xiao Fu" last="Xiao Fu">XIAO FU</name><name sortKey="Xinsong Luo" sort="Xinsong Luo" uniqKey="Xinsong Luo" last="Xinsong Luo">XINSONG LUO</name><name sortKey="Xunya Hou" sort="Xunya Hou" uniqKey="Xunya Hou" last="Xunya Hou">XUNYA HOU</name><name sortKey="Yu, Xin Ling" sort="Yu, Xin Ling" uniqKey="Yu X" first="Xin-Ling" last="Yu">Xin-Ling Yu</name><name sortKey="Yuanyuan Wang" sort="Yuanyuan Wang" uniqKey="Yuanyuan Wang" last="Yuanyuan Wang">YUANYUAN WANG</name><name sortKey="Yuesheng Li" sort="Yuesheng Li" uniqKey="Yuesheng Li" last="Yuesheng Li">YUESHENG LI</name><name sortKey="Zhou Jie" sort="Zhou Jie" uniqKey="Zhou Jie" last="Zhou Jie">ZHOU JIE</name></country><country name="Australie"><noRegion><name sortKey="Mcmanus, Donald P" sort="Mcmanus, Donald P" uniqKey="Mcmanus D" first="Donald P." last="Mcmanus">Donald P. 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